GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs11174436 | 1 | rs12315645 | chr12:62705895 | FAM19A2 | chr12:62102043-62653925:- | 0.17 | 3.65 | 0.00027 | Pyoderma gangrenosum in inflammatory bowel disease |
| BRCA | cis | rs4765219 | 1 | rs12317176 | chr12:124404718 | DNAH10 | chr12:124247042-124420265:+ | 0.26 | 6.51 | 1.14E-10 | Waist-to-hip ratio adjusted for body mass index |
| BRCA | cis | rs11174436 | 1 | rs12317437 | chr12:62738833 | FAM19A2 | chr12:62102043-62653925:- | 0.18 | 3.95 | 8.25E-5 | Pyoderma gangrenosum in inflammatory bowel disease |
| BRCA | cis | rs11174436 | 1 | rs12318287 | chr12:62726856 | FAM19A2 | chr12:62102043-62653925:- | 0.18 | 3.87 | 0.000115 | Pyoderma gangrenosum in inflammatory bowel disease |
| BRCA | cis | rs12324805 | 1 | rs12324805 | chr15:82352200 | GOLGA6L9 | chr15:82711895-82731584:+;chr15 | 0.11 | 3.85 | 0.000125 | Body mass index |
| BRCA | cis | rs12324805 | 1 | rs12324805 | chr15:82352200 | LOC80154 | chr15:82944795-82975797:+;chr15 | 0.15 | 4.55 | 5.92E-6 | Body mass index |
| BRCA | cis | rs10043228 | 1 | rs12332489 | chr5:115579386 | COMMD10 | chr5:115420727-115628978:+ | 0.21 | 4.47 | 8.66E-6 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs10043228 | 1 | rs12332585 | chr5:115581395 | COMMD10 | chr5:115420727-115628978:+ | 0.21 | 4.47 | 8.66E-6 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs7443270 | 1 | rs12332633 | chr5:41233698 | C7 | chr5:40909599-40983039:+ | -0.11 | -4.63 | 4.13E-6 | Response to fenofibrate (adiponectin levels) |
| BRCA | cis | rs10043228 | 1 | rs12332658 | chr5:115545606 | COMMD10 | chr5:115420727-115628978:+ | 0.24 | 5 | 6.85E-7 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs1789924 | 1 | rs1235415 | chr4:100281159 | ADH1C | chr4:100257651-100273917:- | -0.21 | -6.72 | 3.03E-11 | Oral cavity and pharyngeal cancer |
| BRCA | cis | rs11190604 | 1 | rs12354411 | chr10:102294537 | SEC31B | chr10:102246403-102289636:- | -0.3 | -11.18 | 1.69E-27 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs12354486 | 1 | rs12354486 | chr10:104124055 | PITX3 | chr10:103989946-104001231:- | 0.16 | 3.57 | 0.000372 | Educational attainment (college completion) |
| BRCA | cis | rs11190604 | 1 | rs12355721 | chr10:102244911 | SEC31B | chr10:102246403-102289636:- | -0.29 | -10.43 | 2.65E-24 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs7923609 | 1 | rs12355784 | chr10:65121565 | NRBF2 | chr10:64893007-64914785:+ | -0.15 | -5.64 | 2.12E-8 | Educational attainment;Liver enzyme levels (alkaline phosphatase) |